The CACHE (Critical Assessment of Computation Hit-finding Experiments) Challenges offer an open competition platform to help accelerate one of the early stages of drug discovery. Researchers from academia, industry, and nonprofits are invited to deploy their best computational methods to predict molecules that will bind to a predefined target linked to a specific disease, a critical step in the drug discovery pipeline known as hit-finding. Their predictions are evaluated and benchmarked in a state-of-the-art laboratory, by our partners at the Structural Genomics Consortium (SGC). All the benchmarked results are shared openly and publicly with the world, and all chemical structures are made available without patent to all.