5G network infrastructures and embodied technologies are considered as a key asset of this emerging common environment and instrumental for the digitalization of the traditional industries, so-called vertical industry application sectors. Addressing these key questions, the main 5GINFIRE goal is to build and operate an Open, and Extensible 5G NFV-based Reference (Open5G-NFV) ecosystem of Experimental Facilities that not only integrates existing FIRE facilities with new vertical-specific ones but also lays down the foundations for instantiating fully softwarised architectures of vertical industries and experimenting with them.