Planned intervention: On Wednesday April 3rd 05:30 UTC Zenodo will be unavailable for up to 2-10 minutes to perform a storage cluster upgrade.
Published June 15, 2019 | Version 0.99.0
Software Open

sellerslab/gemini: GEMINI: a variational Bayesian approach to identify genetic interactions from combinatorial CRISPR screens

Creators

  • 1. @broadinstitute

Description

Systems for CRISPR-based combinatorial perturbation of two or more genes are emerging as powerful tools for uncovering genetic interactions. However, systematic identification of these relationships is complicated by sample, reagent, and biological variability. We develop a variational Bayes approach (GEMINI) that jointly analyzes all samples and reagents to identify genetic interactions in pairwise knockout screens. The improved accuracy and scalability of GEMINI enables the systematic analysis of combinatorial CRISPR knockout screens, regardless of design and dimension. GEMINI is available as an open source R package on GitHub at https://github.com/sellerslab/gemini.

Files

sellerslab/gemini-0.99.0.zip

Files (4.2 MB)

Name Size Download all
md5:1ba1ecf60e2d4005b54686a091432371
4.2 MB Preview Download

Additional details

Related works