FORMULATION AND DEVELOPMENT OF TRANSDERMAL PATCHES OF AMOXICILLIN AND COMPARATIVE EFFECT OF VARIOUS HERBAL EXTRACTS ON EX VIVO RELEASE

Abstract

In the relentless pursuit of formulating and evaluating transdermal patches incorporating Amoxicillin, this investigation was chiefly orchestrated. A myriad of polymers were harnessed in this endeavour, and a pivotal exploration into the influence of extracts procured from Capsicum Fruit on the bioavailability of Amoxicillin was meticulously undertaken. Scrutiny of utmost precision was dedicated to examining the congruence between the physical and chemical attributes of the pharmaceutical and the foundation of the patches through the employment of Infrared Spectroscopy (FTIR). The resultant findings revealed a remarkable absence of discordance in physical and chemical properties between the medication and the patch substrate. Subsequently, a comprehensive evaluation of the formulated transdermal patches ensued, encompassing meticulous assessments of weight variance, plumpness, folding endurance, humidity levels, moisture retention, ex-vivo drug release, and ex-vivo drug absorption. The discerning diffusion analyses were executed employing the venerable Franz Diffusion cell and the Everted gut Sac method. Among the myriad formulations, denoted as F31, emerged as the paragon of excellence, boasting a thickness of 0.234±0.121mm, a uniform weight distribution at 0.218±0.211gm, moisture uptake measuring 8.249±2.231%, moisture content at 8.671±0.182%, and a drug content of 82.67±0.643%. Furthermore, it showcased an impressive folding endurance of 34±3.13. The zenith of its performance manifested in a cumulative drug release percentage of 3.941±0.41 within an 8-hour temporal span and an absorption rate of 3.571±0.44 % within a 120-minute interval.