Multiple-Unit Pellet System (MUPS): A Review

Pelletization is a technique to convert drugs
or excipients to small free flowing, spherical or semi
spherical units, which are produced by agglomerating
fine powdered drug/excipients with a binder solution.
Pellets range in size, typically, between 0.5 – 2.0 mm.

MUPS (Multiple Unit Pellet Systems) are multi-
particulate in nature and are administered as tablets.

These tablets disperse in stomach and intestine allowing
constant drug release in systemic circulation. This article
reviews the advantages, disadvantages, common
industrial technique for preparation of pellets and
challenges in manufacturing of MUPS.