Published September 28, 2023 | Version v1
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Sequence-to-sequence translation from mass spectra to peptides with a transformer model

Authors/Creators

  • 1. University of Antwerp

Description

  • De novo peptide sequencing can annotate mass spectra with their originating peptides without the requirement for a protein sequence database or needing to know the composition of a sample a priori.
  • We have developed Casanovo, a state-of-the-art de novo peptide sequencing solution based on the popular transformer deep learning architecture.
  • Casanovo significantly outperforms alternative de novo peptide sequencing tools. We demonstrate its state-of-the-art performance on a nine-species benchmark dataset and highlight advances in analyzing immunopeptidomics and metaproteomics data.

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20230928_proteomics_online.pdf

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