Cognitive function in DMD carriers: personal case series and literature review
Authors/Creators
- 1. University of Pavia, Pavia (Italy)
- 2. Info Università Cattolica del Sacro Cuore, Campus di Roma, Rome (Italy)
- 3. Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome (Italy)
- 4. IRCCS Mondino Foundation, Pavia (Italy)
Description
Introduction: This database includes the raw data linked with the paper “Cognitive function in DMD carriers: personal case series and literature review” published on “Acta Myologica”. Aim: This study aimed to investigate the cognitive involvement in a cohort of DMD carriers.
Methods: Our case series consisted of 22 carrier patients from two different centers (IRCCS Mondino, Pa- via and Policlinico Gemelli, Rome), for whom we retrospectively collected cognitive, clinical and genetic data.
Results: We found that the average IQ of DMD carriers was lower (74; very low) than the average score on normal curve (100 as average standard score). Furthermore, about 50% of them fell in the “extremely low IQ” range, compared with 2-3% of general population. A higher incidence of intellectual disability was confirmed in symptomatic DMD carriers (mean IQ 66; extremely low) from the IRCCS Mondino, but not for the asymptomatic ones (mean IQ 99; average), when compared to the general population.
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This data set of raw data is accessible under request by writing to the Scientific Direction of the IRCCS Mondino Foundation (dirsci@mondino.it) specifying:
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