Multivariate GWAS of Alzheimer's disease CSF biomarker profiles implies GRIN2D in synaptic functioning: Summary statistics
- 1. Erasmus University Medical Center
- 2. University of Lübeck
- 3. VIB-UAntwerp Center for Molecular Neurology
Description
Summary statistics for a genome-wide association study (GWAS) of Alzheimer's disease CSF biomarkers principal components (PCs). This dataset accompanies the publication "Multivariate GWAS of Alzheimer’s disease CSF biomarker profiles implies GRIN2D in synaptic functioning". The article is currently in press at Genome Medicine. A link will be provided upon publication, but see the medRxiv preprint in the meantime:
Neumann, A., Ohlei, O., Küçükali, F., Bos, I. J., Vos, S., Prokopenko, D., ... & Kristel Sleegers & Lars Bertram. (2022). Multivariate GWAS of Alzheimer’s disease CSF biomarker profiles implies GRIN2D in synaptic functioning. medRxiv, 2022-08. https://doi.org/10.1101/2022.08.02.22278185
A GWAS was performed for five different PC biomarkers.
PC1: Tau pathology/degeneration
PC2: Aβ Pathology
PC3: Injury/inflammation
PC4: Non-AD inflammation
PC5: Non-AD synaptic functioning
Each GWAS was performed in either males and females ("all"), in females only ("female"), or in males only ("male"). In addition, we also ran an interaction model with sex as moderator ("interaction"). Each file includes output of the meta-analysis between the EMIF-AD study and ADNI.
The files contain following columns:
CHROM: Chromosome
POS: Position according to Build 37
ID: Chromosome:Position
A1: Effect allele
A2: Other allele
BETA: Effect of one copy of the effect allele on biomarker PCs in SD. In case of sex interaction, the effect specific to females.
SE: Standard Error
P: p-value
D: Direction in ADNI and EMIF-AD respectively
Het: Heterogeneity statistics (I2, and corresponding χ2, degrees of freedom and p-value)
Files
Files
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