Published September 11, 2023 | Version v1
Dataset Open

Multivariate GWAS of Alzheimer's disease CSF biomarker profiles implies GRIN2D in synaptic functioning: Summary statistics

  • 1. Erasmus University Medical Center
  • 2. University of Lübeck
  • 3. VIB-UAntwerp Center for Molecular Neurology

Description

Summary statistics for a genome-wide association study (GWAS) of Alzheimer's disease CSF biomarkers principal components (PCs). This dataset accompanies the publication "Multivariate GWAS of Alzheimer’s disease CSF biomarker profiles implies GRIN2D in synaptic functioning". The article is currently in press at Genome Medicine. A link will be provided upon publication, but see the medRxiv preprint in the meantime:

Neumann, A., Ohlei, O., Küçükali, F., Bos, I. J., Vos, S., Prokopenko, D., ... & Kristel Sleegers & Lars Bertram. (2022). Multivariate GWAS of Alzheimer’s disease CSF biomarker profiles implies GRIN2D in synaptic functioning. medRxiv, 2022-08. https://doi.org/10.1101/2022.08.02.22278185

A GWAS was performed for five different PC biomarkers.

PC1: Tau pathology/degeneration

PC2: Aβ Pathology

PC3: Injury/inflammation

PC4: Non-AD inflammation

PC5: Non-AD synaptic functioning

Each GWAS was performed in either males and females ("all"), in females only ("female"), or in males only ("male"). In addition, we also ran an interaction model with sex as moderator ("interaction"). Each file includes output of the meta-analysis between the EMIF-AD study and ADNI.

The files contain following columns:

CHROM: Chromosome

POS: Position according to Build 37

ID: Chromosome:Position

A1: Effect allele

A2: Other allele

BETA: Effect of one copy of the effect allele on biomarker PCs in SD. In case of sex interaction, the effect specific to females.

SE: Standard Error

P: p-value

D: Direction in ADNI and EMIF-AD respectively

Het: Heterogeneity statistics (I2, and corresponding χ2, degrees of freedom and p-value)

Files

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