CRP – a valuable source of information or just a laboratory test?

LESZCZ, Monika, WIĘCKOWSKA-DEROŃ, Marta, NITKA, Karolina, BIAŁEK, Justyna, ĆWIK-BŁOTNICKA, Dominika and BORCZYK, Joanna. CRP – a valuable source of information or just a laboratory test? Journal of Education, Health and Sport. 2023;45(1):366-377. eISSN 2391-8306. https://dx.doi.org/10.12775/JEHS.2023.45.01.026

https://apcz.umk.pl/JEHS/article/view/45359

https://zenodo.org/record/8280352

The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of 17.07.2023 No. 32318. Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).

Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 17.07.2023 Lp. 32318. Posiada Unikatowy Identyfikator Czasopisma: 201159.

Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).

© The Authors 2023;

This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland

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The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 26.07.2023. Revised:21.08.2023. Accepted: 24.08.2023. Published: 29.08.2023.

CRP – a valuable source of information or just a laboratory test?

Monika Leszcz¹, Marta Więckowska-Deroń², Karolina Nitka³, Justyna Białek⁴, Dominika Ćwik-Błotnicka⁵, Joanna Borczyk⁶

Monika Leszcz: https://orcid.org/0000-0002-2041-5890 monika1leszcz@gmail.com

Marta Więckowska-Deroń: https://orcid.org/0000-0002-7811-8370 m.wieckowska9513@gmail.com

Karolina Bieńko: https://orcid.org/0000-0001-7070-9224 bienkokarolina96@gmail.com

Justyna Białek: https://orcid.org/0000-0002-8447-3395 justynabialek111@gmail.com

Dominika Ćwik-Błotnicka: https://orcid.org/0009-0003-2556-2800 cwikblotnicka@gmail.com

Joanna Borczyk: https://orcid.org/0009-0003-5757-6668 asiaborczyk1@gmail.com

¹ Samodzielny Publiczny Zakład Opieki Zdrowotnej w Radzyniu Podlaskim

² Samodzielny Publiczny szpital Kliniczny nr 4 w Lublinie

³ Specjalistyczny Publiczny Szpital Kliniczny nr 1 w Lublinie

⁴ Kliniczny Szpital Wojewódzki Nr 2 im. Św. Jadwigi Królowej w Rzeszowie

⁵ Wojewódzki Szpital Specjalistyczny im. Stefana Kardynała Wyszyńskiego Samodzielny Publiczny Zakład Opieki Zdrowotnej w Lublinie

⁶ Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie

ABSTRACT

Background and Purpose: Laboratory tests are an inseparable element in modern medicine. They provide us with valuable clues for making a diagnosis or monitoring treatment. One of the most frequently ordered biochemical tests is the determination of the level of CRP in the blood. The aim of the study is to present the clinical usefulness of this study and to present knowledge about C-reactive protein.  

Current state of knowledge: It is produced mainly by the liver, but the latest reports confirm local synthesis, among others, in arterial endothelial cells. The most common reason for the increase in the level of CRP is the appearance of infection, during which time its concentration may increase by up to 1000 times. Elderly patients have a weaker immune system response than younger patients, therefore the rise in CRP may be less pronounced. Other reasons are autoimmune diseases, cancer, or acute or chronic inflammation. As a result of cel damage, pro-inflammatory cytokines are secreted, which stimulate the production of CRP. Most scientific sources consider CRP ≥ 10 mg/L to be significant. Values of 3-10mg/L are considered a slight increase in CRP levels. Such CRP values were found in about 1/3 of the American population.

Conclusions:  The CRP level should not be interpreted as an isolated medical parameter, but in conjunction with other tests and the patient's current state of health. Based on the amount of CRP in the blood and changes in its concentration over time, we can check the response to treatment and predict the course of some diseases.

Key words : autoimmune diseases, infections, cancers, CRP protein, inflammations