Synthesis and Evaluation of novel N-(6-nitrobenzo [d] thiazol-2-yl)-2-acetamide as Anthelmintic Activity

With the aim of obtaining newer biologically active compounds, a series of N-(6-nitrobenzo [d] thiazol-2-yl)-2-acetamide) were synthesized (5a-5i). The structures of all the synthesized compounds were confirmed by spectral (FTIR, IR and MS) data and elemental (C, H, N) analysis. Compounds (5a-5i) were screened for anthelmintic activities. Almost all of these compounds showed moderate to excellent anthelmintic activities against Nematode species (Haemonchus contorts). Among the compounds tested, compounds (5b) showed maximum activity against Haemonchus contorts species, respectively. Further Compound exhibited moderate anthelmintic activity comparable to the standard drugs.