Published June 1, 2018 | Version v1
Journal article Open

Retinopathy of Prematurity in Bundelkhand: A Risk Factor Analysis

Authors/Creators

  • 1. Department of Ophthalmology, MLB Medical College, Jhansi
  • 2. Department of Pediatrics, MLB Medical College, Jhansi

Description

Retinopathy of prematurity(ROP) is a vasoproliferative disorder of the retina. It may progress to stage of retinal detachment and blindness. The purpose of this study was to assess the incidence and to identify the risk factors for retinopathy of prematurity (ROP) in bundelkhand region. One Hundred preterm neonates were screened in a tertiary care centre. Proper history, clinical examination and fundus examination of all patients was done and findings were noted. Out of the 50 neonates included in this study, 8 (16%) cases developed ROP in one or both eyes which was further classified as: 5 (62.5%) cases stage 1, 2 (25%) cases stage 2, and 1 (12.5%) case stage 3 with plus disease. None of the studied neonates presented ROP at stages 4 or 5. The incidence of ROP in this study was 16%. On univariate analysis gestational age was an independent risk factor while birth weight and duration of oxygen therapy found to be a relative risk factors. All high risk infants should be screened for ROP.

Files

17-23.pdf

Files (83.8 kB)

Name Size Download all
md5:166a5eba6b4aad28b23273c8338d8092
83.8 kB Preview Download

Additional details

References

  • 1. Azad R, Chandra P. Retinopathy of prematurity. J Indian MedAssoc. 2005;103:370–2.
  • 2. Chaudhari S, Patwardhan V, Vaidya U, Kadam S, Kamat A. Retinopathy of Prematurity in a Tertiary Care Center, Incidence, Risk Factors and Outcomes. Indian Pediatr. 2009;46:219–24..
  • 3. Varughese S, Jain S, Gupta N, Singh S, Tyagi V, Puliyel JM. Magnitude of the problem of retinopathy of prematurity. experience in a large maternity unit with a medium size level-3 nursery. Indian J Ophthalmol 2001;49:187-8
  • 4. Dominico R, Davis K, Davis O. Documenting the NICU design dilemma: Comparative patient progress in openward and single family room units. J Perinatol, 2011;31:281–8.
  • 5. Tasman W. Retinopathy of prematurity: Do we still have a problem?: The Charles L. Schepens lecture. Arch Ophthalmol. 2011;129:1083–6.
  • 6. Kim TI, Sohn J, Pi SY, Yoon YH. Postnatal risk factors of retinopathy of prematurity. Paediatr Perinat Epidemiol. 2004;18:130–4
  • 7. Shah VA, Yeo CL, Ling YL, Ho LY. Incidence, risk factors of retinopathy of prematurity among very low birth weight infants in Singapore. Ann Acad Med Singapore. 2005;34:169–78.
  • 8. Gupta VP, Dhaliwal U, Sharma R, Gupta P, Rohatgi J. Retinopathy of prematurity-risk factors. Indian J Pediatr. 2004;71:887–92.
  • 9. Karna P, Muttineni J, Angell L, Karmaus W. Retinopathy of prematurity and risk factors: A prospective cohort study. BMC Pediatr.2005;5:18
  • 10. Englert JA, Saunders RA, Purohit D, Hulsey TC, Ebeling M. The effect of anemia on retinopathy of prematurity in extremely low birth weight infants. J Perinatol. 2001;21:21–6.
  • 11. Akkoyun I, Oto S, Yilmaz G, Gurakan B, Tarcan A, Anuk D,Akgun S, et al. Risk factors in the development of mild and severe retinopathy of prematurity. J AAPOS. 2006;10:449–53
  • 12. Murthy KR, Nagendra, Babu K, Benakappa N, Niranjan, Murthy PR. Analysis of risk factors for the development of ROP in preterm infants at a tertiary referral hospital in South India. Acta Medica Litunica. 2006;13:147–51.
  • 13. Taqui AM, Syed R, Chaudhry TA, Ahmad K, Salat MS. Retinopathy of Prematurity: Frequency and Risk Factors in a Tertiary Care Hospital in Karachi, Pakistan. J Pak MedAssoc. 2008;58:186–90
  • 14. Kushner BJ, Essner D, Cohen IJ, Flynn JT. Retrolental Fibroplasia. II. Pathologic correlation. Arch Ophthalmol 1977;95:29-38.
  • 15. Fortes Filho JB, Eckert GU, Procianoy L, Barros CK, Procianoy RS. Incidence and risk factors for retinopathy of prematurity in very low and in extremely low birth weight infants in a unit-based approach in southern Brazil. Eye(Lond) 2009;23:25-30
  • 16. Arroe M, Peitersen B. Retinopathy of Prematurity: Review of a seven year period in a Danish neonatal intensive care unit.Acta Pediatr.1994;83:501–5.
  • 17. Smith LE. Pathogenesis of retinopathy of prematurity., .Acta Paediatr Suppl. 2002;437:26–8
  • 18. Vinekar A, Dogra MR, Sangtam T, Narang A, Gupta A. Retinopathy of prematurity in Asian Indian babies weighting greater than 1250 gram at birth; ten years data from tertiary care center in a developing country. Indian J Ophthalmol. 2007;55:331–6.
  • 19. Palmer EA, Hardy RJ, Dobson V, Phelps DL, Quinn GE, Summers CG, et al. Cryotherapy for retinopathy of prematurity cooperative group. Outcomes following threshold retinopathy of prematurity. Final results from the multicenter trial of Cryotherapy for Retinopathy of Prematurity.Arch Ophthalmol. 2005;123:311–18
  • 20. Murthy KR, Nagendra, Babu K, Benakappa N, Niranjan, Murthy PR. Analysis of risk factors for the development of ROP in preterm infants at a tertiary referral hospital in South India. Acta Medica Litunica. 2006;13:147–51.
  • 21. Ikeda H, Kuriyama S. Risk factors for retinopathy of prematurity requiring photocoagulation. Jpn J Ophthalmol. 2004;48:68–71
  • 22. Dutta S, Narang S, Narang A, Dogra M, Gupta A. Risk factors of threshold retinopathy of prematurity. Indian Pediatr. 2004;41:665–71
  • 23. Hirano K, Morinobu T, Kim H, Hiroi M, Ban R, Ogawa S, et al. Blood transfusion increases radical promoting non-transferrin bound iron in preterm infants. Arch Dis Child Fetal Neonatal Ed. 2001;84:188–93
  • 24. Chawla D, Agarwal R, Deorari A, Paul VK, Chandra P, Azad RV. Retinopathy of Prematurity. Indian J Pediatr. 2012;79:501–9
  • 25. Darlow BA, Hutchinson JL, Henderson-Smart DJ, Donoghue DA, Simpson JM, Evans NJ. Australian and New Zealand Neonatal Network.Prenatal risk factors for severe retinopathy of prematurity among very preterm infants of the Australian and New Zealand Neonatal Network. Pediatrics. 2005;115:990–6.
  • 26. Seiberth V, Lindarkomp O. Risk factors in retinopathy of prematurity: A multivariate statistical analysis. Ophthalmologica.2000;214:131–5.
  • 27. Rekha S, Battu RR. Retinopathy of prematurity: incidence and risk factors. Indian Pediatr 1996;33:999- 1003
  • 28. Chaudhari S, Patwardhan V, Vaidya U, Kadam S, KamatA. Retinopathy of Prematurity in a Tertiary Care Center, Incidence, Risk Factors and Outcomes. Indian Pediatr. 2009;46:219–24..
  • 29. Aggarwal R, Deorari AK, Azad RV, et al. Changing profile of retinopathy of prematurity. J Trop Pediatr, 2002;48:239-42.
  • 30. Saunders RA, Donahue ML, Christmann LM, et al. Racial variation in retinopathy of prematurity. The Cryotherapy for Retinopathy of Prematurity Cooperative Group.Arch Ophthalmol 1997;115: 604 -8
  • 31. Hellstrom A, Hard AL, Engstrom E, et al. Early weight gain predicts retinopathy in preterm infants: new, simple, efficient approach to screening. Pediatrics 2009;123:e638-45.
  • 32. HellstromA, Ley D, Hansen-Pupp I, et al. New insights into the development of retinopathy of prematurity - importance of early weight gain.Acta Paediatr 2009.
  • 33. The International Classification of Retinopathy of Prematurity revisited. Arch Ophthalmol. 2005;123: 991-9