Data for investigation of cell-type-specific expression and regulation in Setbp1 (p.S858R) atypical SGS male mice

processed.tar.gz, contains all files from the data directory associated with this projects and includes the following:

• setbp1_targets.csv : list of human SETP1 gene targets from ChIP-seq experiments converted to mouse and enriched for additional interactions from literature references (https://pubmed.ncbi.nlm.nih.gov/35685777/ and https://www.nature.com/articles/s41467-018-04462-8,    
• seurat_objects/
  • kidney_integrated_celltypes.Rdata : filtered and preprocessed seurat object with cell type assignments for input to SoupX processing
  • kidney_integrated_celltypes_postSoup.Rdata : preprocessed and quality controlled seurat object with final cell type assignments after SoupX processing
  • setbp1_cerebralintcelltypes.Rdata : preprocessed and quality controlled seurat object with final cell type assignments
• decoupleR_CollecTRI/
  • mouse_prior_tri.csv : accessed May 2023, it is unclear how versioning or accessions are used so we provided the Mouse CollecTRI (https://github.com/saezlab/CollecTRI) used in this study to calculate cell-type-specific TF activity
• motif_inputs/
  • Mus_motif_all.txt : TF-motif PANDA input for mm10 reference genome enriched for
• expression_inputs/ : expression matrices for all cell types for both tissues and conditions (n = 50) used to construct cell-type-specific PANDA networks

The below files are from the data/results directory of this associated project and include the following:

• alpaca.tar.gz : directory containing differential community analysis outputs from ALPACA
• seurat.tar.gz : directory containing SoupX intermediates, as well as the