PROFILE OF IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME IN HIV INFECTED PATIENTS

Aims : To assess clinical, biochemical and immunological profiles of HIV patients  developing Immune Reconstitution Inflammatory Syndrome(IRIS).

Methods :Cross sectional  study was carried out in  32   cases of HIV infected patients on ART developing IRIS and attending Centre of Excellence(COE) RIMS  and who were  admitted in  Medicine ward, RIMS Hospital. Duration of study was  from October 2014 to September 2016.

Results : The  study showed that  IRIS was found  mainly in the age group of 30-40 years and  more common  among  patients with  BMI  of below 18.5 kg/m2   and  paradoxical  IRIS was more common than unmasking  type of IRIS. Mean duration of development of IRIS  was 87 days  and the most common ART regimen in the study group was Tenofovir+Lamivudine+Efavirenz.  Tuberculosis was the most common opportunistic infection and the  mean baseline CD4 count at the time of initiation of ART  was  167.5 cells/ μl.  At the time of IRIS detection, the  mean increase in CD4 cell count from the time of ART  initiation was  86.66 cells/µl (Mean SD± 61.12cells/ µl.

Conclusion: Tuberculosis was the most common opportunistic infection and paradoxical type of IRIS was more common than unmasking type.

Aims : To assess clinical, biochemical and immunological profiles of HIV patients  developing Immune Reconstitution Inflammatory Syndrome(IRIS).

Methods :Cross sectional  study was carried out in  32   cases of HIV infected patients on ART developing IRIS and attending Centre of Excellence(COE) RIMS  and who were  admitted in  Medicine ward, RIMS Hospital. Duration of study was  from October 2014 to September 2016.

Results : The  study showed that  IRIS was found  mainly in the age group of 30-40 years and  more common  among  patients with  BMI  of below 18.5 kg/m2   and  paradoxical  IRIS was more common than unmasking  type of IRIS. Mean duration of development of IRIS  was 87 days  and the most common ART regimen in the study group was Tenofovir+Lamivudine+Efavirenz.  Tuberculosis was the most common opportunistic infection and the  mean baseline CD4 count at the time of initiation of ART  was  167.5 cells/ μl.  At the time of IRIS detection, the  mean increase in CD4 cell count from the time of ART  initiation was  86.66 cells/µl (Mean SD± 61.12cells/ µl.

Conclusion: Tuberculosis was the most common opportunistic infection and paradoxical type of IRIS was more common than unmasking type.