Data for: Multifunctional fibers enable modulation of cortical and deep brain activity during cognitive behavior in macaques
Authors/Creators
- 1. Massachusetts Institute of Technology
Description
Recording and modulating neural activity in vivo enables investigations of the neurophysiology underlying behavior and disease, but there is a dearth of translational tools for simultaneous recording and localized receptor-specific modulation. We addressed this limitation by translating multifunctional fiber neurotechnology previously only available for rodent studies to enable cortical and subcortical neural recording and modulation in macaques. In the premotor cortex and putamen, we recorded single-neuron activity and local field potential oscillations during intracranial GABA infusions while a macaque performed a working memory task. We also recorded neuronal activity during saline, artificial cerebrospinal fluid, and no infusion control experiments. We characterized the dynamic effects of local infusions with multiple time series analysis techniques, including spectrotemporal analysis and state-space modeling. This dataset and accompanying software toolbox provide detailed insight into the electrophysiological effect of neurotransmitter receptor modulation in both cortical and subcortical structures in an awake macaque.
Notes
All data files are saved as .mat files, which can be opened with MatLab or python. The software is written in MatLab.
The analysis software integrates with the following toolboxes:
Chronux: http://chronux.org/
FOOOF: https://github.com/fooof-tools/fooof
Neurostat: https://github.com/iahncajigas/nSTAT
PPSSM: https://github.com/josefinacmenendez/PPSSM
Funding provided by: McGovern Institute for Brain Research, Massachusetts Institute of Technology
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100019335
Award Number:
Funding provided by: JPB Foundation
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100007457
Award Number:
Funding provided by: National Institute of Neurological Disorders and Stroke
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000065
Award Number: R01-NS115025
Funding provided by: National Institutes of Health
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000002
Award Number: P01-GM118629
Funding provided by: National Institutes of Health
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000002
Award Number: 5T32EB019940-05
Funding provided by: Office of Naval Research
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000006
Award Number: N00014-22-1-2453
Funding provided by: National Institute of Mental Health
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000025
Award Number: 1R01MH131715-01
Funding provided by: National Science Foundation
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000001
Award Number:
Funding provided by: MathWorks
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100014600
Award Number:
Files
README_code.md
Additional details
Related works
- Is cited by
- 10.1101/2022.10.09.511302 (DOI)
- Is derived from
- https://github.com/igarwood/NHP_fibers (URL)
- Is source of
- 10.5061/dryad.zkh1893ft (DOI)