3D Bioprinting in Microgravity: Opportunities, Challenges, and Possible Applications in Space
Authors/Creators
- Angelique van Ombergen
- Franziska Chalupa-Gartner
- Parth Chansoria
- Bianca Maria Colosimo
- Marco Costantini
- Marco Domingos
- Alexandre Dufour
- Carmelo De Maria
- Jurgen Groll
- Tomasz Jungst
- Riccardo Levato
- Jos Malda
- Alessandro Margarita
- Christophe Marquette
- Aleksandr Ovsianikov
- Emma Petiot
- Sophia Read
- Leonardo Surdo
- Wojciech Swieszkowski
- Giovanni Vozzi
- Johannes Windisch
- Marcy Zenobi-Wong
- Michael Gelinsky
Description
3D bioprinting has developed tremendously in the last couple of years and
enables the fabrication of simple, as well as complex, tissue models. The
international space agencies have recognized the unique opportunities of
these technologies for manufacturing cell and tissue models for basic
research in space, in particular for investigating the effects of microgravity
and cosmic radiation on different types of human tissues. In addition,
bioprinting is capable of producing clinically applicable tissue grafts, and its
implementation in space therefore can support the autonomous medical
treatment options for astronauts in future long term and far-distant space
missions. The article discusses opportunities but also challenges of operating
different types of bioprinters under space conditions, mainly in microgravity.
While some process steps, most of which involving the handling of liquids,
are challenging under microgravity, this environment can help overcome
problems such as cell sedimentation in low viscous bioinks. Hopefully, this
publication will motivate more researchers to engage in the topic, with
publicly available bioprinting opportunities becoming available at the
International Space Station (ISS) in the imminent future.
Files
Adv Healthcare Materials - 2023 - Van Ombergen - 3D Bioprinting in Microgravity Opportunities Challenges and Possible.pdf
Files
(4.6 MB)
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