Published June 29, 2023
| Version 3.1.2
Software
Open
SimulaBeta
Authors/Creators
- 1. Ruhr University of Bochum, Germany
- 2. Lee Kong Chian School of Medicine, Nanyang Technological University Singapore
- 1. Ruhr University of Bochum, Germany
- 2. Lee Kong Chian School of Medicine, Nanyang Technological University Singapore
Description
SimulaBeta is a continuous numerical simulation program for insulin-glucose feedback control. It is based on a published nonlinear MiMe-NoCoDI model of insulin-glucose homeostasis, calibrated with physiological data.
Field of analysis supported by the application include:
- Investigating the dynamics of insulin-glucose homeostasis during restoration after perturbations
- Studying the evolution of steady-state concentrations of glucose and insulin depending on constant structure parameters of the feedback loop
- Performing virtual dynamic function tests including intravenous and oral glucose tolerance testing.
- Load, reference and modulation sequencer (LOREMOS) for simulating complex temporal patterns of external influences.
- Basic statistical evaluation of time series
- Two-way sensitivity analysis
The software supports saving and reading parameter sets and sub-models as scenarios and the export of simulation results in various formats for evaluation in statistics packages
Notes
Compiling from source requires Free Pascal and the Lazarus IDE.
Files
SimulaBeta 3.1.2 Source.zip
Files
(43.5 MB)
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Additional details
Identifiers
Related works
- Is cited by
- Journal article: 36271244 (PMID)
- Is described by
- Journal article: 10.1038/s41598-022-22531-3 (DOI)
- Is part of
- Software: https://simulabeta.sourceforge.io/ (URL)
References
- Dietrich JW, Boehm BO. Equilibrium behaviour of feedback-coupled physiological saturation kinetics. Cybernet Syst. (2006) 2006:269–74. https://doi.org/10.13140/2.1.2400.2568
- Berno J.E.Misgeld, Philipp G.Tenbrock, KatrinLunze, Johannes W.Dietrich, SteffenLeonhardt. Estimation of insulin sensitivity in diabetic Göttingen Minipigs. Control Engineering Practice Volume 55, October 2016, Pages 80-90. https://doi.org/10.1016/j.conengprac.2016.06.004
- Johannes W. Dietrich, Bernhard O Böhm. Die MiMe-NoCoDI-Plattform: Ein Ansatz für die Modellierung biologischer Regelkreise. http://dx.doi.org/10.3205/15gmds058
- Johannes W. Dietrich. Systems Endocrinology: Successful Examples of Translational Medicine. Systems Endocrinology: Successful Examples of Translational Medicine
- Dietrich, Johannes W. (2020, April 8). CyberUnits Bricks (Version 1.1.1 (Dendron)). Presented at the GeneSEES 2015 Biocybernetics Workshop, Krefeld, Germany: Zenodo. https://doi.org/10.5281/zenodo.1304179
- Dietrich JW, Dasgupta R, Anoop S, Jebasingh F, Kurian ME, Inbakumari M, Boehm BO, Thomas N. SPINA Carb: a simple mathematical model supporting fast in-vivo estimation of insulin sensitivity and beta cell function. Sci Rep. 2022 Oct 21;12(1):17659. doi: 10.1038/s41598-022-22531-3. PMID: 36271244; PMCID: PMC9587026.