Published June 20, 2023 | Version v1
Dataset Open

Combining Solid-State NMR with Structural and Biophysical Techniques to Design Challenging Protein-Drug Conjugates

Creators

  • 1. University of Florence
  • 2. University of Perugia

Description

Solid-state NMR spectra (DARR and NCA) of rehydrated freeze-dried free TTR and TTR in the presence of Tafamidis and Taf-PTX

Reference citation:  Combining Solid-State NMR with Structural and Biophysical Techniques to Design Challenging Protein-Drug Conjugates. Angew Chem Int Ed Engl. 2023 Jun 5:e202303202. doi: 10.1002/anie.202303202. PMID: 37276329.

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Additional details

Funding

European Commission
iNEXT-Discovery – Infrastructure for transnational access and discovery in structural biology 871037
European Commission
Fragment-Screen – From fragments to high affinity binders interfacing integrated structural biology, medicinal chemistry and artificial intelligence 101094131
European Commission
PANACEA – A Pan-European Solid-State NMR Infrastructure for Chemistry-Enabling Access 101008500
European Commission
HIRES-MULTIDYN – Multiscale Dynamics with Ultrafast High-Resolution Relaxometry 899683
European Commission
GLYTUNES – A multidisciplinary training network for the bioinspired development of glycomimetics tuning the Siglec-Sialoglycan axis 956758