Some novel ways of gastric cancer patients treatment personification

Kirkilevsky S. I., Lurín A. G., Dubinina V. G., Lukyanchuk O. V., Mashukov A. A., Bilenko A. A., Zgura A. N., Osadchy D. N., Maksimovskiy V. E. Some novel ways of gastric cancer patients treatment personification. Journal of Education, Health and Sport. 2017;7(5):516-538. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.801825

http://ojs.ukw.edu.pl/index.php/johs/article/view/4499

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© The Author (s) 2017;

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This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial

use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 05.05.2017. Revised: 23.05.2017. Accepted: 31.05.2017.

UDK 616.33-006.6-089-085.277.3

SOME NOVEL WAYS OF GASTRIC CANCER PATIENTS TREATMENT PERSONIFICATION

S. I. Kirkilevsky1, A. G. Lurín3, V. G. Dubinina2, O. V. Lukyanchuk2,3,

A. A. Mashukov1,2,3, A. A. Bilenko2, A. N. Zgura3, D. N. Osadchy2, V. E. Maksimovskiy2

National Cancer Institute1, Kiev

Odessa National Medical university2, Odessa

Odessa Regional Oncology Center3, Odessa

Abstract

In this paper the authors perform the analysis of molecular and morphological factors influencing the survival of patients with gastric cancer (n = 221). They analyzed the survival rate in this group of patients based on the analysis of molecular markers VEGFR, p53, Her2, Ki-67. Measured role in the survival such factors as the degree of differentiation of primary gastric tumors, the presence of microscopic tumor involvement of perineural and perivascular spaces, the degree of invasion to gastric wall by T1 = 1 and to T4a = 4, T4b = 5, number of regional lymph nodes affected by metastasis, and other factors. As an arbitrator used survival curves calculated by the method of R. J. Cox, time of lifespan, measured in months, as well as a comparison of the areas under the curves of survival.

Keywords: gastric cancer (GC), lymph node dissection, multiorgan resection, immunohistochemistry, genetic classification.