Published June 3, 2023 | Version v1
Dataset Open

Proposed catalytic mechanism of mAMCase.

  • 1. University of California, San Francisco

Description

This directory contains all files required to analyze the proposed catalytic mechanism of mouse AMCase at pH 2.0 and 6.5 presented in Figure 6 in the manuscript Díaz et al. (2023).

Structure models were analyzed using PyMOL. Figures were compiled using PerkinElmer ChemDraw and Adobe Illustrator.

Files included in this directory:

 

 

Figures

- contains ChemDraw file for the proposed catalytic mechanism schematic, PNGs of each step of the proposed catalytic mechanism at pH 2.0 and 6.5, and a GIF of the entire proposed catalytic mechanism at pH 2.0 and 6.5.

 

PyMOL

- contains all structure models, PyMOL script, and PyMOL session used to generate Figure 6.

 

Contact:
Roberto Efraín Díaz, robertoefrain.diaz@ucsf.edu

James Fraser, jfraser@fraserlab.com

Files

Catalytic Mechanism.zip

Files (15.0 MB)

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md5:7649348e2d01d1eff120a3ace2117738
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Additional details

Funding

Targeting chitin in fibrotic lung disease 5R01HL148033-03
National Institutes of Health

References

  • Díaz, Roberto Efraín et al. (2023). Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase.