The solution to drug resistance of Gram-negative bacteria – Cefiderocol

KOŁODZIEJ, Magdalena, GORCZYCA, Kamila, JASTRZĘBSKA, Ilona, WĘGOROWSKI, Paweł & WIECZOREK, Michał. The solution to drug resistance of Gram-negative bacteria – Cefiderocol. Journal of Education, Health and Sport. 2023;33(1):17-21. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2023.33.01.002

https://apcz.umk.pl/JEHS/article/view/43777

https://zenodo.org/record/7962694

The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.

Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).

Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.

Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).

© The Authors 2023;

This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland

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The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 29.04.2023. Revised: 10.05.2023. Accepted: 23.05.2023. Published: 23.05.2023.

The solution to drug resistance of Gram-negative bacteria – Cefiderocol

Magdalena Kołodziej 1, https://orcid.org/0000-0002-6597-1559, magdalenakolodziej502@gmail.com 

Kamila Gorczyca 2, https://orcid.org/0000-0002-7976-0509, kamila.gorczyca@o2.pl

Ilona Jastrzębska 1, https://orcid.org/0000-0001-6754-529X, ilonaj14@gmail.com

Dr Paweł Węgorowski 3, https://orcid.org/0000-0001-6077-7653, wegorpl@wp.pl

Dr Michał Wieczorek 3, https://orcid.org/0000-0002-3204-5022, wieczorek.michal@gmail.com

1. Medical University of Lublin,
2. Department of Obstetrics and Perinatology, Medical University of Lublin
3. Vincent Pol University in Lublin.

Corresponding authors: Magdalena Kołodziej, magdalenakolodziej502@gmail.com;

Abstract

Introduction: A major public health problem is the emergence of anti-gram-negative antimicrobial resistance worldwide. Cefiderocol is a new agent targeting Gram-negative bacteria, including strains with resistance to carbapenems.

Aim of the study: Analysis of the efficiency of cefiderocol in the treatment of infections caused by gram-negative bacteria, the drug's mechanism of action and pharmacokinetics and pharmacodynamics of the drug.

Material and Methods: Search of the PubMed database using the following keywords: cefiderocol, resistance, gram negative bacteria. Only full-length articles were taken into consideration.

Results: The studies show that cefiderocol is active against Enterobacteriaceae, P. aeruginosa, B. cepacia and A. baumannii and effective in the treatment of pneumonia in both non-ventilated and ventilated patients. Moreover, it has been used in the treatment of sepsis as a rescue therapy.

Conclusion: Cefiderocol is an effective treatment for infections caused by gram-negative bacteria. However, more research is needed to learn more about the use of this drug, side effects and resistance mechanisms.

Keywords: cefiderocol, resistance, gram negative bacteria