Published April 24, 2023
| Version v1
Journal article
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Nitroreductase-sensitive fluorescent covalent organic framework for tumor hypoxia imaging in cells
Description
Covalent organic frameworks (COFs) have been used in cell imaging, but very rarely for imaging specific cell conditions. Herein, a β-ketoenamine-based fluorescent COF was post-synthetically modified to incorporate a hypoxia-targeting molecule. Fluorescence microscopy imaging shows that the material discriminates between HeLa cells grown under hypoxia and those cultured under normoxia.