Published May 17, 2023 | Version v1
Dataset Open

Specific CD4+ T cell phenotypes associate with bacterial control in people who 'resist' infection with Mycobacterium tuberculosis

Authors/Creators

  • 1. Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Palo Alto, CA, USA
  • 2. Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA
  • 3. Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA, USA and Department of Epidemiology and Population Health, School of Medicine, Stanford University, Stanford, CA, USA
  • 4. Department of Immunology and Microbiology, University of Colorado, Anschutz Medicine Campus, Aurora, CO, USA
  • 5. Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA, USA and Center for Biomedical Informatics Research, Department of Medicine, Stanford University, Stanford, CA, USA
  • 6. Human Immune Monitoring Center, Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA, USA
  • 7. Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA, USA and Human Immune Monitoring Center, Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA, USA
  • 8. Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA, USA and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
  • 9. Division of Medical Oncology, Rutgers Cancer Institute of New Jersey, Department of Medicine, Rutgers Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA
  • 10. Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA, USA; Center for Biomedical Informatics Research, Department of Medicine, Stanford University, Stanford, CA, USA; and Department of Biomedical Data Sciences, School of Medicine, Stanford University, Stanford, CA, USA
  • 11. Department of Medicine, Case Western Reserve University, Cleveland, OH, USA
  • 12. Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA
  • 13. Department of Medicine, Makerere University School of Medicine, Kampala, Uganda
  • 14. Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Palo Alto, CA, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA; and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA

Description

The repository contains the processed Seurat object generated from SELECT-seq data of ESAT-6/CFP-10-specific T cells sorted from PBMC of household contacts of sputum culture-positive cases of pulmonary TB (four subjects with latent TB infection (LTBI) and three M. tuberculosis 'resisters' (RSTR)).

Information on how the Seurat object was analyzed can be found in this GitHub respository: https://github.com/ttsunmeng/TB_RSTR_ESAT6CFP10_SelectSeq_analysis_pipeline.

The full details of this cohort have been previously published here:

  • Stein, C.M., et al. Long-term Stability of Resistance to Latent Mycobacterium tuberculosis Infection in Highly Exposed Tuberculosis Household Contacts in Kampala, Uganda. Clin Infect Dis 68, 1705-1712 (2019).
  • Stein, C.M., et al. Resistance and Susceptibility to Mycobacterium tuberculosis Infection and Disease in Tuberculosis Households in Kampala, Uganda. Am J Epidemiol 187, 1477-1489 (2018).

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