Published May 11, 2023 | Version v1
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STUDY OF LETHAL DOSE (LD50) DETERMINATION AND BODY/ ORGAN WEIGHT OF RATS ADMINISTERED AQUEOUS EXTRACT OF EQUAL WEIGHT OF PAWPAW (Carica papaya) AND SOURSOP (Annona muricata)LEAVE

Authors/Creators

  • 1. AMBROSE ALLI UNIVERSITY BIOCHEMISTRY DEPARTMENT P.M.B 14 EKPOMA, NIGERIA
  • 2. DEPARTMENTAL OF CHEMICAL SCIENCE, DELTA STATE UNIVERSITY OF SCIENCE AND TECHNOLOGY OZORO

Description

This study determineslethal dose toxicity (LD50)and effect on body/organ of rat administered equal weight of pawpaw (Carica papaya) and soursop (Annona muricata) leaves extra. About 125g each of the sample where mixed, extracted with 200ml of ethanol in triplicate and concentrated. The concentrated sample was used to prepare different dilution for the study. LD50 was asserted with a concentration range of 6.67-60.5mg in 150g rats. The effect on body weight and organ weight were studied with concentration range of 27.60mg/kg to 70.43 mg/kg body weight of rats. The LD50 was found to be 54.11mg/150g rats (equivalent to 3607.52mg/kg body weight). With exception of rat in group D (i.e., 10% above safe dose), rats administered the respective extract recorded non-significant (p>0.05) higher weight compared to rats in control group. The  study suggest that the extract is slightly toxic, not convient to transport but had insignificant effect on body/ organ weight.

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References

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Subjects

Biological & Medicine Science
http://www.gphjournal.org/index.php/bs/article/view/843