Individual variability in structural brain development with respect to sex and puberty

As we move toward population-level developmental neuroscience, understanding intra- and interindividual variability in brain maturation and sources of neurodevelopmental heterogeneity becomes paramount. Large-scale, longitudinal neuroimaging studies have uncovered group-level neurodevelopmental trajectories, and while recent work has begun to untangle intra- and interindividual differences, they remain largely unclear. Here, we aim to quantify both intra- and inter-individual variability across facets of neurodevelopment from late childhood to early adolescence in the Adolescent Brain Cognitive Development (ABCD) Study, and examine the contributions of age, sex, and puberty to inter-individual variability. Our results provide novel insight into differences in microstructure development between cortical and subcortical gray matter. We found that an individual’s starting point is related to how their brain changes, across all brain outcomes. Although both sex and pubertal status contributed to inter-individual variability, we found limited support for hypotheses regarding greater male-than-female variability and increases in inter-individual variability throughout puberty. This work highlights pockets of individual variability across facets of development and across the brain for future investigation, while describing a promising approach for quantifying deviations from normative development.