Published February 17, 2023
| Version 1.1.0
Dataset
Open
orthosData
Authors/Creators
- 1. Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland - SIB Swiss Institute of Bioinformatics
Contributors
Researchers:
- 1. Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland - SIB Swiss Institute of Bioinformatics
Description
`orthosData` is the companion database to the `orthos` software for mechanistic studies using differential gene expression experiments.
It currently encompasses data for over 100,000 differential gene expression mouse and human experiments distilled and compiled from the ARCHS4 database* as well as associated pre-trained variational models.
Together with `orthos` it was developed to provide a better understanding of the effects of experimental treatments on gene expression and to help map treatments to mechanisms of action.
Notes
*Lachmann A, Torre D, Keenan AB, Jagodnik KM, Lee HJ, Wang L, Silverstein MC, Ma'ayan A. Massive mining of publicly available RNA-seq data from human and mouse. Nature Communications 9. Article number: 1366 (2018), doi:10.1038/s41467-018-03751-6
Files
Files
(64.2 GB)
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