Published May 3, 2023 | Version v1
Dataset Open

Data from: Compensatory growth is accompanied by changes in insulin-like growth factor-1 but not markers of cellular aging in a long-lived seabird

  • 1. Loyola University Chicago
  • 2. North Dakota State University
  • 3. University of Minnesota


Developing organisms often plastically modify growth in response to environmental circumstances, which may be adaptive, but is expected to entail long-term costs. However, the mechanisms that mediate these growth adjustments and any associated costs are less well understood. In vertebrates, one mechanism that may be important in this context is the highly conserved signaling factor insulin-like growth factor-1 (IGF-1), which is often positively related to post-natal growth and negatively related to longevity. To test this idea, we exposed captive Franklin's gulls (Leucophaeus pipixcan) to a physiologically relevant nutritional stressor by restricting food availability during post-natal development and examined the effects on growth, IGF-1, and two potential biomarkers of cellular and organismal aging (oxidative stress, and telomeres). During food restriction, experimental chicks gained body mass more slowly and had lower IGF-1 levels than controls. Following the food restriction, experimental chicks underwent compensatory growth, which was accompanied by an increase in IGF-1 levels. Interestingly however, there were no significant effects of the experimental treatment or of variation in IGF-1 levels on oxidative stress or telomeres. These findings suggest that IGF-1 is responsive to changes in resource availability but is not associated with increased markers of cellular aging during development in this relatively long-lived species.


R is needed to open the R script, all excel files have been uploaded as .csv.

Funding provided by: North Dakota Established Program to Stimulate Competitive Research
Crossref Funder Registry ID:
Award Number: FAR0022429

Funding provided by: National Science Foundation
Crossref Funder Registry ID:
Award Number: 1845974



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