ENHANCING PERMEABILITY OF ACYCLOVIR BY LIPOSOMAL DRUG DELIVERY SYSTEM

Liposomes are derived from Greek word lipo means fat and soma means body, composition
of phospholipids these are made up of phospholipids bi layer, encapsulated in both
hydrophilic and lipophilic drugs and safe guard from decoration these formulations due to its
biodegradable and biocompatible characteristics, many drug delivery applications have been
fully examined over the last decade. Acyclovir is BCS Class III drug with low permeability.
To enhance the permeability of acyclovir drug by liposomal drug delivery system by thin film
lipid hydration by hand shake method. Acyclovir liposomes are penetrated to biological
membrane and enhance their pharmacological action and drug release. Enhance the rate of
drug permeability is enhanced there by increases the Bioavailability of poorly BCS class III
drug – Acyclovir and improved therapeutic efficacy and compliance of the patient. Recent
trends so many students and research scholars desire and signifance will increase for this
technology mainly because of wide range of therapeutic applications in targeting delivery of
several enzymes’ antibiotics anti virals,anti-parasite transdermal transports and diagnostic
tools and vaccines. The goal of topical liposome delivery approaches is to get access by
combining different polymers.