Published March 28, 2023 | Version v1
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Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson's disease

Description

Auxilin participates in clathrin uncoating to facilitate presynaptic endocytosis. Loss-of-function mutations of auxilin (PARK19) cause Parkinson’s disease. Using auxilin KO mice, Vidyadhara et al. (2023) show that synaptic vesicle sorting deficits, cytoplasmic dopamine accumulation, dopamine transporter mistrafficking, and synaptic autophagic overload may lead to pathogenesis of Parkinson’s disease in PARK19 patients. This file contains the data set used to generate all the main figures.

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Additional details

Related works

Is source of
Journal article: 10.1016/j.celrep.2023.112231 (DOI)

Funding

Adaptive immunity in the etiology and progression of Parkinson’s disease ASAP-000375
Aligning Science Across Parkinson's
Tracing the Origin and Progression of Parkinson’s Disease through the Neuro-Immune Interactome ASAP-000529
Aligning Science Across Parkinson's