Published March 19, 2023
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Anti-Cancer properties of Taxol
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Abstract:
Taxol, a chemotherapeutic agent derived from Taxus species, particularly Taxus baccata and wallichiana, has been widely used in the treatment of various cancers, including ovarian, breast, and lung cancer. Taxol has been shown to have potent anti-cancer properties due to its ability to inhibit microtubule depolymerization, resulting in cell cycle arrest and apoptosis. This paper reviews the chemistry of Taxol and its pharmacokinetics, as well as the anti-cancer properties of Taxus baccata and wallichiana. The paper also explores other medicinal herbs that have been shown to have anti-cancer properties.
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- Is published in
- Journal article: 10.4135/foobar.135 (DOI)
References
- Cragg, G. M., & Newman, D. J. (2013). Natural products: a continuing source of novel drug leads. Biochimica et Biophysica Acta (BBA)-General Subjects, 1830(6), 3670-3695. Kingston, D. G. (2007). Taxol, a molecule for all seasons. Chemical Communications, (5), 507-514. Ojha, R., Aryal, U. K., Adhikari, S., & Devkota, H. P. (2017). Chemical constituents and biological activities of the genus Taxus: a review. Chemistry Central Journal, 11(1), 103. Roos, W. P., & Kaina, B. (2013). DNA damage-induced cell death by apoptosis. Trends in Molecular Medicine, 19(12), 714-725. Sharma, R. A., & Gescher, A. J. (2013). Staging of curcumin's potential against cancer: how is it done? Free Radical Research, 47(11), 893-905. Siddiqui, I. A., & Adhami, V. M. (2016). Possible chemopreventive effects of green tea nutrients in cancer. European Journal of Cancer Prevention, 25(6), 524-532. Xu, H., Wang, Y., & Lin, X. (2018). Recent advances in the discovery and development of natural products as source for anti-cancer agents. European Journal of Medicinal Chemistry, 157, 647-665.
Subjects
- Biochemistry, Botany
- 4135