Published October 26, 2022
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Cationic amphiphilic drugs as potential anticancer therapy for PDAC
Authors/Creators
- 1. Institute for Oncology and Radiology of SerbiaBelgrade, Serbia, Department of Experimental Oncology and Radiology, Belgrade, Serbia
- 2. Innovative Centre of the Faculty of Chemistry in BelgradeLtd., Department of Organic Chemistry, Belgrade, Serbia
- 3. Faculty of Chemistry- University of Belgrade- Belgrade, Serbia, Department of Organic Chemistry, Belgrade, Serbia
- 4. Institute for Molecular Genetics and Genetical Engineering- Belgrade, Department for Microbial Molecular Genetics and Ecology, Belgrade, Serbia
- 5. 5 Institute for Oncology and Radiology of SerbiaBelgrade, Serbia, Department of Experimental oncology, Belgrade, Serbia
- 6. Serbian Academy of Sciences and Arts, Department of Chemistry, Belgrade, Serbia
- 7. Institute for Oncology and Radiology of Serbia- Belgrade, Serbia, Department for experimental oncology, Belgrade, Serbia
Description
Pancreatic ductal adenocarcinoma (PDAC) is the sixth leading cause of death worldwide. PDAC carries a 5-y survival of less than 10%, as it is often diagnosed at a late stage and is widely refractory to available therapies. PDAC tumors are hypoperfused, resulting in poor nutrient delivery. To exist in this hostile microenvironment, PDAC cells rely on intracellular and extracellular scavenging pathways to acquire metabolic substrates for growth. Autophagy and other lysosome-dependent recycling pathways are aberrantly regulated in PDAC. Although autophagy modulation is an emerging therapeutic strategy for PDAC, the co-dependences induced by lysosomal inhibition have not been systematically explored.
Notes
34th EORTC-NCI-AACR Symposium on Molecular
Targets and Cancer Therapeutics
26–28 October 2022
Barcelona. Spain. Abstract Book. Poster Session
6065979
Publication of this supplement was supported by the EORTC
Volume 174S1
October 2022
34th EORTC-NCI-AACR Symposium on Molecular
Targets and Cancer Therapeutics
26–28 October 2022
Barcelona, Spain
Publication of this supplement was supported by the EORTC
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- Conference paper: 0959-8049 (ISSN)
- Conference paper: event.eortc.org/ena2022/abstract/ (Handle)