Published November 8, 2022 | Version v1
Conference paper Open

Functionalized Mesoporous Silica Nanoparticles for Drug Delivery to Glioblastoma Multiforme

Creators

  • 1. BioSense Institute, University of Novi Sad, Dr Zorana Djindjica 1, 21000 Novi Sad, Serbia
  • 2. Technical University of Munich, Am Coulombwall 3, 85748 Garching, Germany
  • 3. Department of Engineering and Natural Sciences, University of Applied Sciences Merseburg, Eberhard-Leibnitz- Strasse 2, 06217 Merseburg, Germany

Description

Mesoporous silica nanoparticles (MSN) are covalently functionalized with Ir(III)-based complex and further characterized by nitrogen sorption, SEM, FTIR, EDS, TGA, DSC, DLS and zeta potential measurements. Controlled, pHresponsive delivery Ir(III)-complexes was noticed and demonstrated for efficient treatment of glioblastoma multiforme (GBM) cells upon exposure to acidification.

Notes

The authors acknowledge financial support from the German Academic Exchange Service (DAAD) [grant number: 57393212]. This Research was supported by the Science Fund of the Republic of Serbia, PROMIS, #6060755, PRECAST (N.Ž.K) and has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement 952259 (NANOFACTS).

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