Ovarian function decline investigated through transcriptomic analysis of female rabbits at different parities

Additionally, transcriptome analysis was applied to the ovarian tissues of rabbits in the P2 and P6 groups, and 213 up-regulated and 747 down-regulated genes were identified. Within the list of DEGs, are genes related to reproductive function, including CYP21A2, BRCA1, PTGFR, SGK1, PIK3R6, and SRD5A2. This study therefore reveals novel insights into the molecular mechanisms underpinning ovarian failure of female rabbits induced by multiple pregnancies.