Supplementary files of "Association between plasminogen activator inhibitor-1 and osimertinib tolerance in EGFR-mutated lung cancer via epithe-lial–mesenchymal transition"

Supplementary FIgures: The following supporting information can be downloaded. Figure S1: Structure of SK-216. Figure S2: Concentration of PAI-1 protein in the culture medium. Figure S3: Evaluation of the knockdown efficiency of PAI-1. Figure S4; Analysis of the gene copy number of MET and HER2. Figure S5: The genes expression involved in TGF-β induced EMT pathway b in the microarray data.

Supplementary Methods: The following supporting information can be downloaded. Isolation and culture of cancer cells obtained from a patient. The primers used for Quantitative real time PCR (qRT-PCR). EGFR T790M, C797S mutation, gene copy number analyses.