Recent Advances in Metal−Organic Frameworks for Applications in Magnetic Resonance Imaging
Creators
- 1. Institute of Physics, University of Augsburg, D-86159 Augsburg, Germany
- 2. Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, 140 21 Prague 4, Czech Republic
Description
Diagnostics is an important part of medical practice.
The information required for diagnosis is typically collected by
performing diagnostic tests, some of which include imaging.
Magnetic resonance imaging (MRI) is one of the most widely used
and effective imaging techniques. To improve the sensitivity and
specificity of MRI, contrast agents are used. In this review, the
usage of metal−organic frameworks (MOFs) and composite
materials based on them as contrast agents for MRI is discussed.
MOFs are crystalline porous coordination polymers. Due to their huge design variety and high density of metal ions, they have been
studied as a highly promising class of materials for developing MRI contrast agents. This review highlights the most important
studies and focuses on the progress of the field over the last five years. The materials are classified based on their design and
structural properties into three groups: MRI-active MOFs, composite materials based on MOFs, and MRI-active compounds loaded
in MOFs. Moreover, an overview of MOF-based materials for heteronuclear MRI including 129Xe and 19F MRI is given.
Notes
Files
2022_Bunzen_Jirak_AMI_Metal-organic_frameworks.pdf
Files
(8.7 MB)
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