Published June 8, 2023 | Version v1
Dataset Open

Human Genetics Influences Microbiome Composition Involved in Asthma Exacerbations despite Inhaled Corticosteroid Treatment

Authors/Creators

  • 1. Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna (ULL), La Laguna, Tenerife, Spain.
  • 2. Pulmonary Medicine Service, Hospital Universitario de N.S de Candelaria, La Laguna, Tenerife, Spain.
  • 3. Severe Asthma Unit, Allergy Department, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain.
  • 4. Department of Medicine, University of California San Francisco (UCSF), San Francisco, CA, USA.
  • 5. Division of Pediatric Respiratory Medicine, Hospital Universitario Donostia, San Sebastián, Spain.
  • 6. Allergy Department, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain.
  • 7. CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.

Description

Additional Supplement Data of the manuscript Perez-Garcia J, Espuela-Ortiz A, Hernández-Pérez JM, et al. Human Genetics Influences Microbiome Composition Involved in Asthma Exacerbations despite Inhaled Corticosteroid Treatment (in press). J Allergy Clin Immunol. 2023;S0091-6749(23)00748-0. doi:10.1016/j.jaci.2023.05.021.

This Supplement Data contains the following items:

Additional Table 1 List of independent mbQTLs associated with p<1x10-5 in the mbGWAS from saliva samples in Europeans (discovery).
Additional Table 2 List of independent mbQTLs associated with p<1x10-5 in the mbGWAS from pharyngeal samples in Europeans (discovery).
Additional Table 3 List of independent mbQTLs associated with p<1x10-5 in the mbGWAS from nasal samples in Europeans (discovery).
Additional Table 4 Summary results of enrichment analyses using the Enrichr platform.
Additional Table 5 Summary results of stratified enrichment analyses by biological sample type.
Additional Table 6 List of independent mbQTLs associated with p<1x10-5 in the mbGWAS from saliva samples in African Americans (replication phase).
Additional Table 7 List of independent mbQTLs associated with p<1x10-5 in the mbGWAS from saliva samples in Latinos (replication phase).
Additional Table 8 Summary results of replication enrichment analyses in saliva samples.
Additional Table 9 Summary statistics of the mbQTL analysis of Streptococcus in nasal samples.
Additional Table 10 Summary statistics of the mbQTL analysis of Campylobacter in pharyngeal samples.
Additional Table 11 Summary statistics of the mbQTL analysis of Tannerella in pharyngeal samples.
Additional Table 12 Summary table of the different genetic models tested for each mbQTL pair.

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Related works

Is part of
Journal article: 10.1016/j.jaci.2023.05.021 (DOI)

References

  • Perez-Garcia J, Espuela-Ortiz A, Hernández-Pérez JM, et al. Human Genetics Influences Microbiome Composition Involved in Asthma Exacerbations despite Inhaled Corticosteroid Treatment [published online ahead of print, 2023 Jun 8]. J Allergy Clin Immunol. 2023;S0091-6749(23)00748-0. doi:10.1016/j.jaci.2023.05.021