Dataset related to article "A comprehensive investigation of histotype-specific microRNA and their variants in stage I epithelial ovarian cancers"
Authors/Creators
- 1. University of Padova, Department of Biology, Padova, Italy
- 2. Mario Negri Institute for Pharmacological Research, Department of Oncology, Milan, Italy AND Medical Genetics Unit, ASST Santi Paolo e Carlo, Milan, Italy
- 3. University of Milano-Bicocca, Department of Obstetrics and Gynaecology, San Gerardo Hospital, Monza, Italy
- 4. IRCCS Humanitas Research Hospital, Molecular Pharmacology Lab, Rozzano, Italy
- 5. University of Brescia, Department of Molecular and Translational Medicine, Brescia, Italy
- 6. University of Milano-Bicocca, Department of Pathology, San Gerardo Hospital, Monza, Italy
- 7. Azienda Ospedaliero-Universitaria Città della Salute, Presidio S Anna and Department of Surgical Science, Gynecology, University of Torino, Torino, Italy
- 8. Gynaecology and Obstetrics 1, Dept of Surgical Sciences, St Anna Hospital and University of Torino, Turin, Italy
- 9. IRCCS Humanitas Research Hospital, Cancer Pharmacology, Pieve Emanuele, Italy AND Humanitas University, Department of Biomedical Sciences, Pieve Emanuele, Italy
Description
This record contains data related to article “A comprehensive investigation of histotype-specific microRNA and their variants in stage I epithelial ovarian cancers".
isomiRs, the sequence-variants of microRNA, are known to be tissue and cell type specific but their physiological role is largely unknown. In this study we explored for the first time the expression of isomiRs across different stage I epithelial ovarian cancer (EOC) histological subtypes, in order to shed new light on their biological role in tumor growth and progression. In a multi-centric retrospective cohort of tumor biopsies (n=215) we sequenced small RNAs finding 971 expressed miRNAs, 64% of which are isomiRs. Among them, 42 isomiRs showed a clear histotype specific pattern, confirming our previously identified miRNA markers (miR192/194 and miR30a-3p/5p for mucinous and clear cell subtypes respectively) and uncovering new biomarkers for all the five subtypes. Using integrative models, we found that the 38% of these miRNA expression alterations is the result of copy number variations while the 17% of differential transcriptional activities. Our work represents the first attempt to characterize isomiRs expression in stage I EOC within and across subtypes and to contextualize their alterations in the framework of the large genomic heterogeneity of this tumor.
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Additional details
Related works
- Is supplement to
- 10.1002/ijc.34408 (DOI)
- 36541726 (PMID)