Published December 8, 2022
| Version v1.0
Software
Open
MC profiling: a novel approach to analyze DNA methylation heterogeneity in genome-wide bisulfite sequencing data
Authors/Creators
- 1. University of Naples Federico II
Description
We propose Methylation Class (MC) profiling as a genome-wide approach to the study of DNA methylation heterogeneity from bulk bisulfite sequencing experiments. The proposed approach is built on the concept of MCs, groups of DNA molecules sharing the same number of methylated cytosines. The relative abundances of MCs from sequencing reads incorporates the information on the average methylation, and directly informs on the methylation level of each molecule.
Files
EpigenomicsLAB/MCprofiling_code-v1.0.zip
Files
(1.8 MB)
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Additional details
Related works
- Is supplement to
- https://github.com/EpigenomicsLAB/MCprofiling_code/tree/v1.0 (URL)