Published December 7, 2022
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Preparation and Development of Diclofenac Loaded Aloevera Gel Nanoparticles for Transdermal Drug Delivery Systems
Description
The objective of this study was to preparation and development of Diclofenac loaded aloevera gel nanoparticles for transdermal drug delivery system. The application of CCD is a useful tool for optimizing DCloaded alovera gel nanoparticles prepared by the emulsion solvent evaporation technique. The optimized nanoparticles obtained displayed an average particle size of 226.83 nm with a norrow polydispersity index (0.271), an EE of 49.9 % and a slow and prolonged drug release over a period of 24 hours. Ethylcellulose nanoparticles of Diclofenac sodium can be of significant practical use for a sustaining drug release and decreasing side effects.
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