Antispermatogenic Activity of Momordica Dioica Methanolic Root Extract

Population explosion is a global phenomenon and has robust impact on various global issues. It is a major concern for public policy makers and governments. Hence, there is a need for an ideal contraceptive with maximum efficacy and safety. Many plant based products have antispermatogenic activity that needs to be investigated. In this context, the current study evaluates the antispermatogenic potential of methanolic crude extract of roots of Momordica dioica on experimental rats. Experiments were carried out by administering the root extract of M. dioica at different dose levels of 10, 20 and 50 mg/kg body weight/day for 60 days on male albino rats. The reproductive organ weights of experimental rats were analyzed manually of different dose levels. Effect of the drug was examined by serum Testosterone, LH and FSH levels. Sperm morphology and motility was observed in semen of cauda epididymis. Histological sections of rat testis and epididymis were studied. The effect of root extract of M. dioica showed significant decrease in the weights of reproductive organs and hormonal levels.There was a significant change and decrease in sperm morphology and motility respectively in the experimental rats after administering with the above drug. Histological examination of testis and epididymis of experimental rats showed degeneration as compared to the control group. The present research concludes the effectiveness of M. dioica root in posing the antispermatogenic activity.