Resveratrol impacts health in patients with diabetes mellitus and other metabolic conditions

Nowak, Emilia, Psiuk, Dominika, Rocka, Agata, Dycha, Natalia, Jasielski, Patryk, Jasielska, Faustyna, Madras, Dominika, Rocka, Ewelina. Resveratrol impacts health in patients with diabetes mellitus and other metabolic conditions. Journal of Education, Health and Sport. 2022;12(11):341-346. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2022.12.11.045

https://apcz.umk.pl/JEHS/article/view/39978

https://zenodo.org/record/7305232

 

 

 

 

 

The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.

Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).

Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.

Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).

© The Authors 2022;

This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland

Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.

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The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 13.09.2022. Revised: 20.10.2022. Accepted: 06.11.2022.

 

 

Resveratrol in diabetes mellitus and other metabolic conditions

Emilia Nowak, Dominika Psiuk, Agata Rocka, Natalia Dycha, Patryk Jasielski, Faustyna Jasielska, Dominika Madras, Ewelina Rocka

Emilia Nowak

Faculty of Medicine, Medical University of Lublin, Chodźki Street 19, 20-093 Lublin

https://orcid.org/0000-0003-4012-2419

emilia.m.nowak@wp.pl

 

Dominika Psiuk

Faculty of Medicine, Medical University of Lublin, Chodźki Street 19, 20-093 Lublin

https://orcid.org/0000-0003-3319-3489

dominika.psiuk@gmail.com

 

Agata Rocka

Faculty of Medicine, Medical University of Lublin, Chodźki Street 19, 20-093 Lublin

https://orcid.org/0000-0003-4738-3160

agatarocka2@gmail.com

 

Natalia Dycha

Faculty of Pharmacy, Medical University of Lublin, Chodźki Street 19, 20-093 Lublin

https://orcid.org/0000-0002-5212-7463

dycha_natalia@interia.pl

 

Patryk Jasielski

Faculty of Medicine, Medical University of Lublin, Chodźki Street 19, 20-093 Lublin

https://orcid.org/0000-0002-0958-735X

patryk.jasielski111@gmail.com

 

Faustyna Jasielska

Faculty of Medicine, Medical University of Lublin, Chodźki Street 19, 20-093 Lublin

https://orcid.org/0000-0002-8280-498X

faustyna.jasielska@gmail.com

 

Dominika Madras

Faculty of Medicine, Medical University of Lublin, Chodźki Street 19, 20-093 Lublin

https://orcid.org/0000-0002-1777-4403

dkmadras@gmail.com

Ewelina Rocka

Faculty of Medical Denistry, Medical University of Lublin, Chodźki Street 19, 20-093 Lublin

https://orcid.org/0000-0002-0767-4863

ewelina-ro@wp.pl

 

Abstract

Introduction and purpose

Resveratrol is a polyphenol with many properties, including activity against glycation, oxidative stress, inflammation, neurodegeneration, carcinogenesis and aging. It appears to be a promising compound for the prevention and treatment of metabolic diseases. The aim of this review is to summarize the results of the latest clinical trials that concern effects of resveratrol in diabetes mellitus type 1 and 2 and its complications - diabetic foot ulcers, diabetic nephropathy and non-alcoholic fatty liver disease.

 

A brief description of the state of knowledge

Based on in vitro studies and animal models, it has been observed that resveratrol reverses the factors causing premature death: obesity, hypertension, and hyperlipidemia. Because of its anti-inflammatory, antioxidant, cardioprotective and blood lowering glucose effects, it appears to be a promising compound for the treatment of metabolic conditions. The review presents different clinical trials concerning the efficiency of resveratrol supplementation in patients with diabetes mellitus and metabolic syndrome and their complications. Most studies focused on assessing the effect of resveratrol supplementation as an adjunctive treatment of diabetes mellitus type 2 and in this group of patients it gave the best results causing reduction of fasting glucose levels, fasting insulin concentration, insulin resistance and improvement of insulin sensitivity and lipid profiles.

 

Conclusions

Resveratrol remains a potential drug in the treatment of metabolic diseases like diabetes mellitus. However, the results of the conducted trials are inconscient. More research is needed to confirm the effectiveness of resveratrol supplementation in treating diabetes, its complications and other metabolic conditions.

 

Keywords: resveratrol; diabetes; metabolism