Serum and synovial Interleukin–17A level in Rheumatoid arthritis patients and its relation to disease activity

ABSTRACT

Objective:

The aim of this study was to measure the level of IL-17A in the serum and synovial fluid of patients with rheumatoid arthritis and correlated its level with disease activity.

Patients and methods:

One hundred patients suffering from rheumatoid arthritis, their ages ranged between 20 to 69 years (42.7±SD11.3). Their disease duration ranged from 2 to 23 years (6.8±SD4.1) and fifty age and sex matched control. All patients and control were subjected to clinical, laboratory investigation and measurement of serum IL-17A. And the patients group only were subjected to synovial fluid IL17A by ELISA technique.

Results:

There were statistical significant increase in the serum IL17A level (p value<0.05) in the RA patients than control and in the patients with high disease activity than those with low disease activity. There were statistical significant increases in the synovial IL17A level in the patients with high disease activity than those with low disease activity.

Conclusion:

In our study; the mean serum IL-17A level was found with high titre in patients than control and higher in patients with high disease activity than in those with low disease activity. The mean synovial IL-17A level was found with high titre in patients with high disease activity than in those with low disease activity. The positive correlation between the serum and synovial IL17A in the patients groups.

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