Fraunhofer ITMP ScreeningPort
Published October 12, 2022 | Version v1.0
Poster Open

BPO: the Bioassay Protocol Ontology, a semantic approach to elevate the reusability of AMR-related drug discovery data

Authors/Creators

  • 1. Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP)
  • 2. Paul-Ehrlich-Institut
  • 3. Statens Serum Institut
  • 4. Luxembourg Centre for Systems Biomedicine
  • 5. European Molecular Biology Laboratory
  • 6. University of Oxford e-Research Centre
  • 7. The University of Manchester

Description

To enhance the reproducibility and usability of bioassays in antimicrobial resistance (AMR) associated antibacterial drug discovery and development, there is an increasing need for standardisation of bioassay metadata into machine-readable formats. Such a standardisation process requires mapping bioassay data to standard ontologies and can be performed at the study result output and protocol levels. At the result output level, general ontologies such as the BioAssay Ontology (BAO) already exist. Still, antibacterial drug discovery and AMR-specific ontologies that can aid in the standardisation process at the protocol level are missing. Hence, we propose a new application-specific ontology that will enable researchers to convert unstructured bioassay protocol data into structured machine-readable formats thereby promoting their overall reusability.

Notes

We have made the ontology available for community reuse on GitHub https://github.com/Fraunhofer-ITMP/bpo.

Files

ESCMID_BPO_Poster.pdf

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Additional details

Funding

European Commission
COMBINE - Collaboration for Prevention and Treatment of MDR Bacterial Infections 853967
European Commission
FAIRplus - FAIRplus 802750