DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR TACROLIMUS IN BULK AND MARKETED GEL

Tacrolimus (FK506) is a calcineurin inhibitor and immunosuppressant. It has the chemical formula C₄₄H₆₉NO₁₂ and is a 23-membered macrolide lactone. (Figure 1) that was discovered for the first time in 1987 in Streptomyces tsukubaensis. The US Food and Drug Administration (USFDA) originally approved it for liver transplantation in 1994.