Potential in anti-cancer therapy using RNA - overview of therapies

Rusinowska Barbara. Potential in anti-cancer therapy using RNA - overview of therapies. Journal of Education, Health and Sport. 2022;12(7):817-827. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2022.12.07.082

https://apcz.umk.pl/JEHS/article/view/JEHS.2022.12.07.082

https://zenodo.org/record/6920482

The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.

Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).

Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.

Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).

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Received: 16.07.2022. Revised: 17.07.2022. Accepted: 28.07.2022.

Potential in anti-cancer therapy using RNA - overview of therapies

Authors: Barbara Rusinowska

Affiliation: Student Research Group at the Chair and Department of Epidemiology and Clinical Research Methodology; Medical University of Lublin

Contact: rusinowskabarbara4@gmail.com; +48 794303542

Orcid: 0000-0002-8207-1042

Abstract

The main targets for the production of mRNA-based tumor vaccines are tumor-associated antigens and tumor-specific neoepitopes exposed on the surface of tumor cells. Their mission is to stimulate the cellular response in the body of a sick patient. In producing of mRNA vaccines it is important to use an appropriate vector and method of delivery of the vaccine to the body. Recent years a lot of interest has been seen in using dendritic cells as a vector. Ugur Sahin and his associates were the first to create procedures for creating personalized mRNA mutanomic vaccines. Apart from mutanomes, miRNA – the type of interference RNAs regulating gene expression - played a role in the development of mRNA vaccines. It has been shown that miRNA dysregulation is observed in some cancers and plays a role in invasion, angiogenesis, apoptosis, avoidance of immune destruction or sensitivity to growth factors. Many of the functions of LncRNA affect gene expression by regulating chromatin function, affecting the stability and translation of cytoplasmic mRNA, and signaling pathways, may ultimately lead to cancer formation – and also can be used in anti-cancer therapy and as sensitive biomarkers. These discoveries led to the rapid development of RNA-based anti-cancer therapies and the emergence of the first therapeutics. In this review, we present the use of RNA in anti-cancer therapies and the review of thrapies.

Key words: RNA; mRNA; LncRNA, miRNA; anti-cancer therapy; therapeutics