Published November 1, 2022
| Version v1
Dataset
Open
Integration of single-cell transcriptome and chromatin accessibility of early gonads development among goats, pigs, macaques, and humans
Authors/Creators
- Chen, Min1
- Long, Xin1
- Chen, Min1
- Hao, Fei1
- Kang, Jia2
- Wang, Nan1
- Wang, Yuan3
- Wang, Mengyue1
- Gao, Yuan4
- Zhou, Mei4
- Duo, Lei4
- Zhe, Xiaoshu4
- He, Jiafu4
- Ren, Bingxu4
- Zhang, Yaoguang4
- Liu, Bowen1
- Li, Jiayi1
- Zhang, Qiancheng1
- Yan, Long1
- Cui, Xiuhong1
- Wang, Yaqing5
- Gui, Yaoting6
- Wang, Hongmei1
- Zhu, Lan3
- Liu, Dongjun4
- Guo, Fan1
- Gao, Fei1
- 1. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
- 2. Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China
- 3. Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 1 Shuaifu Road, Dongcheng District, Beijing 100730, China.
- 4. State Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, Inner Mongolia University, Hohhot 010000, China
- 5. State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
- 6. Guangdong and Shenzhen Key Laboratory of Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen 518036, China
Description
The early gonads of mammals contain primordial germ cells (PGCs) and somatic cell precursors that are essential for sex determination and gametogenesis. Although it is extensively documented in mice, the development of early gonads in non-rodents remains to be delineated. Because molecular differences between mouse and human gonadal cells have been reported, it warrants the study of the key markers and regulatory features that are conserved or divergent between non-rodent species and human. Here, we integrate single-cell transcriptome and chromatin accessibility analysis to identify regulatory signatures of PGCs and somatic cells in the early gonads of goats, pigs, macaques, and humans. We identify the evolutionarily conserved and species-specific events, including genes expression, signaling pathways, and cell-cell interactions. We also uncover potential cis-regulatory elements and key transcription factors in PGCs and somatic cells. Our datasets provide important resources for better understanding the evolutionary programs of PGCs and gonadal somatic cell development in mammals.
Files
goat_ov_E34_singlecell.csv
Files
(26.6 GB)
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