"AN EXPEDIENT APPROACH FOR ONE-POT SYNTHESIS OF 1,8-NAPHTHYRIDINE DERIVATIVES"

An efficient method has been described for the synthesis of 1,8-naphthyridine derivatives. A reaction of 2-amino pyridine, malononitrile and aromatic aldehydes was carried out in presence of lanthanum chloride as catalyst at room temperature to produce ,8-naphthyridines. The short reaction time, mild reaction condition and excellent yield are the remarkable features of this method.