Published October 28, 2025 | Version v1.4
Software Open

cblaster: a remote search tool for rapid identification and visualisation of homologous gene clusters

Description

This release resolves some long standing bugs and adds support for searching against the ClusteredNR database.

What's Changed

  • Initial support for searches against the ClusteredNR database (NR database clustered at 90% identity). To enable, specify nr_cluster_seq as a database when performing remote mode searches, e.g.: cblaster search -qf query.fasta -m remote -db nr_cluster_seq. This should give significantly faster remote searches compared to the regular NR database (which remains the default). Note that query sequences are only searched against NR cluster representative sequences; clusters are then expanded to include other sequences in the cluster, and hit data (identity, coverage, evalue, bitscore) for all member sequences are taken from the representative hit.
  • Don't add empty sequences to DB so diamond does not fail by @biobeni in https://github.com/gamcil/cblaster/pull/122
  • Fix GenBank parsing when first gene wraps chromosome start/end by @biobeni in https://github.com/gamcil/cblaster/pull/121
  • Fix missing database and empty .fasta file error by @kaileyhh in https://github.com/gamcil/cblaster/pull/111
  • Lowered default hitlist size to 500 to avoid BLAST result errors
  • Fixed search bug caused by query sequence headers containing whitespace

New Contributors

  • @biobeni made their first contribution in https://github.com/gamcil/cblaster/pull/122
  • @kaileyhh made their first contribution in https://github.com/gamcil/cblaster/pull/111

Full Changelog: https://github.com/gamcil/cblaster/compare/v1.3.20...v1.4

Notes

If you use this software, please cite it as below.

Files

gamcil/cblaster-v1.4.zip

Files (16.5 MB)

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Additional details

Related works

Is supplement to
Software: https://github.com/gamcil/cblaster/tree/v1.4 (URL)

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