Guidelines on Biochemical/Hematological Monitoring of COVID-19 Patients
Authors/Creators
- 1. Senior Lab Tech, PCLMA, KFMC, Riyadh, Saudi Arabia
- 2. Lab Tech I, PCLMA, KFMC, Riyadh, Saudi Arabia
- 3. Medical Technologist II, PCLMA, KFMC, Riyadh, Saudi Arabia
Description
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease in 2019 (COVID-19) which rapidly evolved from an outbreak in Wuhan, China into a pandemic that has resulted in over millions of infections and over hundreds of thousands of mortalities worldwide. Various coagulopathies have been reported in association with COVID-19, including disseminated intravascular coagulation (DIC), sepsis-induced coagulopathy (SIC), local microthrombi, venous thromboembolism (VTE), arterial thrombotic complications, and thrombo-inflammation. There is a plethora of publications and conflicting data on hematological and hemostatic derangements in COVID-19 with some data suggesting the link to disease progress, severity and/or mortality. There is also growing evidence of potentially useful clinical biomarkers to predict COVID-19 progression and disease outcomes. Of those, a link between thrombocytopenia and COVID-19 severity or mortality was suggested. In this opinion report, we examine the published evidence of hematological and hemostatic laboratory derangements in COVID-19 and the interrelated SARS-CoV-2 induced inflammation.
Keywords: biochemistry; new coronary pneumonia; hematology; SARS-CoV-2.
Title: Guidelines on Biochemical/Hematological Monitoring of COVID-19 Patients
Author: Yasir.A.Ahmed, Ayeed Marfo AlEnizi, Mansour Farhan AlEnizi, Fahad Mohammed AlWallan
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
Vol. 10, Issue 1, April 2022 - September 2022
Page No: 90-99
Research Publish Journals
Website: www.researchpublish.com
Published Date: 28-June-2022
DOI: https://doi.org/10.5281/zenodo.6771809
Paper Download Link (Source)
Notes
Files
Guidelines on Biochemical-28062022-2.pdf
Files
(824.2 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:881e99439495dda14e24fcbde1732653
|
824.2 kB | Preview Download |
Additional details
Related works
- Is derived from
- Journal article: https://www.researchpublish.com/papers/guidelines-on-biochemicalhematological-monitoring-of-covid-19-patients (URL)
- Is published in
- Journal article: 2348-5728 (ISSN)
References
- [1] Singh A, Sood N, Narang V, Goyal A. Morphology of COVID- 19-affected cells in peripheral blood film. BMJ Case Rep 2020;13: e236117.
- [2] Huang I, Pranata R. Lymphopenia in severe coronavirus disease- 2019 (COVID-19): systematic review and meta-analysis. J. Intensive Care 2020; 8: 36.
- [3] Henry BM, De Oliveira MHS, Benoit S, Plebani M, Lippi G. Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis. Clin Chem Lab Med 2020; 58: 1021–8.
- [4] Zhang J, Dong X, Cao Y, Yuan Y, Yang Y, Yan Y, et al. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Eur J Allergy Clin Immunol 2020; 75: 1730–41.
- [5] Bao J, Li C, Zhang K, Kang H, Chen W, Gu B. Comparative analysis of laboratory indexes of severe and non-severe patients infected with COVID-19. Clin Chim Acta 2020; 509: 180–94.
- [6] Lagunas-Rangel FA. Neutrophil-to-lymphocyte ratio and lymphocyte-to-C-reactive protein ratio in patients with severe coronavirus disease 2019 (COVID-19): a meta-analysis. J Med Virol Apr 3 2020. https://doi.org/10.1002/ jmv.25819 [Epub ahead of print].
- [7] Becker RC. COVID-19 update: covid-19-associated coagulopathy. J Thromb Thrombolysis 2020; 50: 54–67.
- [8] Lippi G, Sanchis-Gomar F, Henry BM. COVID-19: unravelling the clinical progression of nature's virtually perfect biological weapon. Ann Transl Med 2020; 8: 693.
- [9] Bikdeli B, Madhavan MV, Jimenez D, Chuich T, Dreyfus I, Driggin E, et al. COVID-19 and thrombotic or thromboembolic disease: implications for prevention, antithrombotic therapy, and followup: JACC state-of-the-art review. J Am Coll Cardiol 2020; 75: 2950–73.
- [10] Bikdeli B, Madhavan MV, Gupta A, Jimenez D, Burton JR, Der Nigoghossian C, et al. Pharmacological agents targeting thromboinflammation in COVID-19: review and implications for future research. Thromb Haemost 2020; 120: 1004–24.
- [11] Leppkes M, Knopf J, Naschberger E, Lindemann A, Singh J, Herrmann I, et al. Vascular occlusion by neutrophil extracellular traps in COVID-19. EBio Med 2020; 58: 10295.
- [12] Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost 2020; 18: 1233–4.
- [13] Gando S, Fujishima S, Saitoh D, Shiraishi A, Yamakawa K, Kushimoto S, et al. The significance of disseminated intravascular coagulation on multiple organ dysfunction during the early stage of acute respiratory distress syndrome. Thromb Res 2020; 191: 15–21.
- [14] Lippi G, Favaloro EJ. D-dimer is associated with severity of coronavirus disease 2019: a pooled analysis. Thromb Haemost 2020; 120: 876–7.
- [15] Al-Samkari H, Karp Leaf RS, Dzik WH, Carlson JC, Fogerty AE, Waheed A, et al.COVIDand coagulation: bleedingand thrombotic manifestations of SARS-CoV2 infection. Blood 2020; 136: 489–500.
Subjects
- Paper Download Link (Source)
- https://www.researchpublish.com/papers/guidelines-on-biochemicalhematological-monitoring-of-covid-19-patients