Oxidation of Hydroxyzine with Potassium Permanganate: A Kinetic Study

Hydroxyzine a pharmaceutical used as antihistamine is oxidized with potassium permanganate to study its kinetics at various temperatures. The rate of reaction was observed is first order with respect to substrate and oxidant whereas it is independent on acid medium. There is no effect of salt on the rate of reaction and no polymerization initiated during the reaction. The final product obtained is identified as hydroxyzine Noxide. The suitable mechanism is proposed and rate law is derived.