Integrative Modeling
Published May 19, 2022 | Version 3
Dataset Open

Molecular architecture of nucleosome remodeling and deacetylase sub-complexes by integrative structure determination

Authors/Creators

  • 1. National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India
  • 2. School of Chemistry and Molecular Biosciences, University of Queensland, QLD, Australia
  • 3. School of Life and Environmental Sciences, University of Sydney, NSW, Australia

Description

Drawing on information from SEC-MALLS, DIA-MS, XLMS, negative-stain EM, X-ray crystallography, NMR spectroscopy, secondary structure predictions, and homology models, we applied Bayesian integrative structure determination to investigate the molecular architecture of three NuRD sub-complexes: MTA1-HDAC1-RBBP4 (MHR), MTA1N-HDAC1-MBD3GATAD2CC (MHM), and MTA1-HDAC1-RBBP4-MBD3-GATAD2A (NuDe). The present dataset pertains to the results of this study.

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nurd.zip

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Additional details

Related works

Is derived from
Dataset: https://github.com/isblab/nurd (URL)